|
KMID : 0387420090200020047
|
|
Korean Society of Oriental Neuropsychiatry
2009 Volume.20 No. 2 p.47 ~ p.60
|
|
|
Effects of Samjung-hwan(S?nj?ngwan) on Obesity and Lipid Metabolism in Rats with High Fat Diet
|
|
Koo Byung-Su
Kim Geun-Woo
Kim Ji-Hyung
|
|
|
Abstract
|
|
|
Objectives: This study was performed to show the effects of Samjung-hwan (S?nj?ngwan) extract on obesity and lipid metabolism of rats fed high fat diet.
Methods: Crushed Samjung-hwan(S?nj?ngwan) 245 g was extracted with methyl alcohol. The extract was evaporated under reduced pressure to give 21.8 g. 20 rats were divided into normal, control, and two test groups. For 6 weeks, The normal group rats were supplied with a normal diet. The control group rats were supplied with a high fat diet. The test group 1 rats were supplied with a high fat diet and Samjung-hwan(S?nj?ngwan) extract 250 mg/kg and the test group 2 rats were supplied witha high fat diet and Samjunghwan(S?nj?ngwan) extract 500 mg/kg.
Results: 1) The control group rats showed significantly increased weight of peritoneal fat than the nornal group rats. The test group 1 rats did not show significant difference compare to the control group rats, and the test group 2 rats showed significantly decreased weight of peritoneal fat than the control group rats. 2) The control group rats showed significantly increased triglyceride than the nornal group rats. The test group 1 rats showed significantly decreased triglyceride than the control group rats, and the test group 2 rats showed significantly decreased triglyceride than the control group rats. 3) The control group rats showed significantly increased LDL-cholesterol than the nornal group rats. The test group 1 rats showed significantly decreased LDL-cholesterol than the control group rats, and the test group 2 rats did not show significant difference compare to the control group rats.
Conclusions: These results suggest that effectiveness of Samjung-hwan(S?nj?ngwan) extract to control the obesity and abnormal lipid metabolism caused by a high fat diet.
|
|
|
KEYWORD
|
|
|
Samjung-hwan(S?nj?ngwan), Obesity, Lipid metabolism, Peritoneal fat, Triglyceride, LDL-cholesterol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|